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ID: ALA2176875

Journal: Bioorg Med Chem Lett

Title: Ago-allosteric modulators of human glucagon-like peptide 2 receptor.

Authors: Yamazaki K, Terauchi H, Iida D, Fukumoto H, Suzuki S, Kagaya T, Aoki M, Koyama K, Seiki T, Takase K, Watanabe M, Arai T, Tsukahara K, Nagakawa J.

Abstract: Glucagon-like peptide 2 (GLP-2) is an intestinotropic peptide that binds to GLP-2 receptor (GLP-2R), a class-B G protein-coupled receptor (GPCR). Few synthetic agonists have been reported so far for class-B GPCRs. Here, we report the first scaffold compounds of ago-allosteric modulators for human GLP-2R, derived from methyl 2-{[(2Z)-2-(2,5-dichlorothiophen-3-yl)-2-(hydroxyimino)ethyl]sulfanyl}benzoate (compound 1).

CiteXplore: 22944117

DOI: 10.1016/j.bmcl.2012.08.026