Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family.

ID: ALA2177102

Journal: Bioorg Med Chem Lett

Title: Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family.

Authors: Finlay MR, Griffin RJ.

Abstract: Modulation of DNA repair pathways in oncology has been an area of intense interest in the last decade, not least as a consequence of the promising clinical activity of poly(ADP-ribose) polymerase (PARP) inhibitors. In this review article, we highlight inhibitors of the phosphatidylinositol 3-kinase related kinase (PIKK) family as of potential interest in the treatment of cancer, both in combination with DNA-damaging therapies and as stand-alone agents.

CiteXplore: 22835870

DOI: 10.1016/j.bmcl.2012.06.053

Patent ID: ┄