Antiproliferative activity of salinomycin and its derivatives.

ID: ALA2202961

Journal: Bioorg Med Chem Lett

Title: Antiproliferative activity of salinomycin and its derivatives.

Authors: Huczyński A, Janczak J, Antoszczak M, Wietrzyk J, Maj E, Brzezinski B.

Abstract: Antiproliferative activity of seven amides and one benzotriazole ester derivative of salinomycin, a polyether ionophore antibiotic, with recently reported antibacterial activity, are herein described. Salinomycin and the majority of derivatives exhibit potent antiproliferative activity against the drug-resistant cancer cell lines. Moreover almost all derivatives show stronger activity against LoVo/DX cell line than that of unmodified salinomycin.

CiteXplore: 23079523

DOI: 10.1016/j.bmcl.2012.09.068

Patent ID: ┄