Document Report Card

ID: ALA2203037

Journal: ACS Med Chem Lett

Title: Synthesis and Anti-influenza A Virus Activity of 2,2-Dialkylamantadines and Related Compounds.

Authors: Torres E, Fernández R, Miquet S, Font-Bardia M, Vanderlinden E, Naesens L, Vázquez S.

Abstract: The synthesis of several 2,2-dialkyladamantyl-1-amines through the combination of a Ritter reaction with a Wagner-Meerwein rearrangement from noradamantane alcohols is reported. Several of the novel amines displayed low micromolar activities against several H1N1 influenza virus strains, including the amantadine-resistant A/PuertoRico/8/34 strain. Most of the compounds did not show cytotoxicity for MDCK cells.

CiteXplore: 24900429

DOI: 10.1021/ml300279b