Synthetic bicyclic iminosugar derivatives fused thiazolidin-4-one as new potential HIV-RT inhibitors.

ID: ALA2203139

Journal: Bioorg Med Chem Lett

Title: Synthetic bicyclic iminosugar derivatives fused thiazolidin-4-one as new potential HIV-RT inhibitors.

Authors: Chen H, Yang T, Wei S, Zhang H, Li R, Qin Z, Li X.

Abstract: Novel bicyclic iminosugar derivatives fused thiazolidin-4-one were conveniently synthesized by double Pummerer rearrangements, and their HIV reverse transcriptase (RT) inhibitory activities were preliminary examined. The notable anti-HIV-RT activity demonstrated that such bicyclic azasugars hold potential as a new kind of HIV-RT inhibitors.

CiteXplore: 23067552

DOI: 10.1016/j.bmcl.2012.09.100

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