Document Report Card

ID: ALA2331077

Journal: J Nat Prod

Title: Sacchathridine A, a prostaglandin release inhibitor from Saccharothrix sp.

Authors: Nakae K, Kurata I, Kojima F, Igarashi M, Hatano M, Sawa R, Kubota Y, Adachi H, Nomoto A.

Abstract: Sacchathridine A (1) was isolated from the fermentation broth of strain Saccharothrix sp. MI559-46F5. The structure was determined as a new naphthoquinone derivative with an acetylhydrazino moiety by a combination of NMR, MS spectral analyses, and chemical degradation. Compound 1 showed inhibitory activity of prostaglandin E2 release in a concentration-dependent manner from human synovial sarcoma cells, SW982, with an IC50 value of 1.0 μM, but had no effect on cell growth up to 30 μM.

CiteXplore: 23581596

DOI: 10.1021/np3006327