Isolation and structures of axistatins 1-3 from the Republic of Palau marine sponge Agelas axifera Hentschel .
Basic Information
ID: ALA2331138
Journal: J Nat Prod
Title: Isolation and structures of axistatins 1-3 from the Republic of Palau marine sponge Agelas axifera Hentschel .
Authors: Pettit GR, Tang Y, Zhang Q, Bourne GT, Arm CA, Leet JE, Knight JC, Pettit RK, Chapuis JC, Doubek DL, Ward FJ, Weber C, Hooper JN.
Abstract: An investigation begun in 1979 directed at the Republic of Palau marine sponge Agelas axifera Hentschel for cancer cell growth inhibitory constituents subsequently led to the isolation of three new pyrimidine diterpenes designated axistatins 1 (1), 2 (2), and 3 (3), together with the previously reported formamides 4, 5, and agelasine F (6). The structures were elucidated by analysis of 2D-NMR spectra and by HRMS. All of the isolated compounds were found to be moderate inhibitors of cancer cell growth. Axistatins 1-3 (1-3), formamide 4, and agelasine F (6) also exhibited antimicrobial activity.
CiteXplore: 23410078
DOI: 10.1021/np300828y
Patent ID: ┄