Document Report Card

ID: ALA2331235

Journal: J Nat Prod

Title: Solphenazines A-F, glycosylated phenazines from Streptomyces sp. strain DL-93.

Authors: Rusman Y, Oppegard LM, Hiasa H, Gelbmann C, Salomon CE.

Abstract: During a survey of actinobacteria known to suppress the growth of Streptomyces scabies (the causative agent of potato scab disease) in vivo, six new rhamnosylated alkaloids, the solphenazines A-F (1-6), were isolated from a biological control strain of Streptomyces (DL-93). The known rhamnosyl analogue of paraben (9) was also isolated along with a new rhamnosylated derivative of N-methyl-p-aminobenzoic acid (10). None of the compounds exhibited any antibacterial or antifungal activity against a standard panel of microorganisms, but compounds 1, 2, and 6 displayed some cytotoxicity against HCT-116 cancer cells. Additional in vitro testing provided data suggesting that the cytotoxic activity is not due to DNA intercalation or topoisomerase inhibition.

CiteXplore: 23317013

DOI: 10.1021/np3007606