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ID: ALA2331374
Journal: Bioorg Med Chem
Title: Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN).
Authors: Ma C, Jin K, Cao J, Zhang L, Li X, Xu W.
Abstract: Aminopeptidase N (APN/CD13) over expressed on tumor cells, plays a critical role in tumor invasion, metastasis, and tumor angiogenesis. Here we described the design, synthesis and preliminary activity studies of novel leucine ureido derivatives as aminopeptidase N (APN/CD13) inhibitors. The results showed that compound 8c had the most potent inhibitory activity against APN with the IC50 value to 0.06 ± 0.041 μM, which could be used for further anticancer agent research.
CiteXplore: 23453219