Synthesis of derivatives of methyl rosmarinate and their inhibitory activities against matrix metalloproteinase-1 (MMP-1).
Basic Information
ID: ALA2331379
Journal: Eur J Med Chem
Title: Synthesis of derivatives of methyl rosmarinate and their inhibitory activities against matrix metalloproteinase-1 (MMP-1).
Authors: Yuan H, Lu W, Wang L, Shan L, Li H, Huang J, Sun Q, Zhang W.
Abstract: A series of MMP-1 inhibitors have been identified based upon a methyl rosmarinate scaffold using structure-based drug design methods. The best compound in the series showed an IC50 value of 0.4 μM. A docking study was conducted for compound (S)-10n in order to investigate its binding interactions with MMP-1. The structure-activity relationships (SAR) were also briefly discussed. Useful SAR was established which provides important guidelines for the design of future generations of potent inhibitors against MMP-1.
CiteXplore: 23353736
DOI: 10.1016/j.ejmech.2012.09.047
Patent ID: ┄