Document Report Card

Basic Information

ID: ALA2331413

Journal: Bioorg Med Chem Lett

Title: Novel in vivo active anti-malarials based on a hydroxy-ethyl-amine scaffold.

Authors: Ciana CL, Siegrist R, Aissaoui H, Marx L, Racine S, Meyer S, Binkert C, de Kanter R, Fischli C, Wittlin S, Boss C.

Abstract: A novel series of anti-malarials, based on a hydroxy-ethyl-amine scaffold, initially identified as peptidomimetic protease inhibitors is described. Combination of the hydroxy-ethyl-amine anti-malarial phramacophore with the known Mannich base pharmacophore of amodiaquine (57) resulted in promising in vivo active novel derivatives.

CiteXplore: 23260352

DOI: 10.1016/j.bmcl.2012.11.118