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ID: ALA2331433
Journal: Bioorg Med Chem Lett
Title: Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors.
Authors: Ting PC, Lee JF, Zorn N, Kim HM, Aslanian RG, Lin M, Smith M, Walker SS, Cook J, Van Heek M, Lachowicz J.
Abstract: The structure-activity relationship studies of a novel series of carboxylic acid derivatives of pyridine-carboxamides as DGAT-1 inhibitors is described. The optimization of the initial lead compound 6 based on in vitro and in vivo activity led to the discovery of key compounds 10j and 17h.
CiteXplore: 23317570