Synthesis of antioxidants for prevention of age-related macular degeneration.

ID: ALA2331545

Journal: J Nat Prod

Title: Synthesis of antioxidants for prevention of age-related macular degeneration.

Authors: Joshi D, Field J, Murphy J, Abdelrahim M, Schönherr H, Sparrow JR, Ellestad G, Nakanishi K, Zask A.

Abstract: Photooxidation of A2E may be involved in diseases of the macula, and antioxidants could serve as therapeutic agents for these diseases. Inhibitors of A2E photooxidation were prepared by Mannich reaction of the antioxidant quercetin. These compounds contain water-solubilizing amine groups, and several were more potent inhibitors of A2E photooxidation than quercetin.

CiteXplore: 23346866

DOI: 10.1021/np300769c

Patent ID: ┄