Document Report Card

ID: ALA2375233

Journal: J Nat Prod

Title: Cytotoxic phorbol esters of Croton tiglium.

Authors: Zhang XL, Wang L, Li F, Yu K, Wang MK.

Abstract: Chemical investigation of the seeds of Croton tiglium afforded eight new phorbol diesters (three phorbol diesters, 1-3, and five 4-deoxy-4α-phorbol diesters, 4-8), together with 11 known phorbol diesters (nine phorbol diesters, 9-17, and two 4-deoxy-4α-phorbol diesters, 18 and 19). The structures of compounds 1-8 were determined by spectroscopic data information and chemical degradation experiments. The cytotoxic activities of the phorbol diesters were evaluated against the SNU387 hepatic tumor cell line, and compound 3 exhibited the most potent activity (IC50 1.2 μM).

CiteXplore: 23701597

DOI: 10.1021/np300832n