Exploration of the structure-activity relationship of a novel tetracyclic class of TSPO ligands-potential novel positron emitting tomography imaging a...
Basic Information
ID: ALA2375274
Journal: Bioorg Med Chem Lett
Title: Exploration of the structure-activity relationship of a novel tetracyclic class of TSPO ligands-potential novel positron emitting tomography imaging agents.
Authors: O'Shea D, Ahmad R, Årstad E, Avory M, Chau WF, Durrant C, Hirani E, Jones PA, Khan I, Luthra SK, Mantzilas D, Morisson-Iveson V, Passmore J, Robins EG, Shan B, Wadsworth H, Walton S, Zhao Y, Trigg W.
Abstract: A series of novel TSPO ligands based on the tetracyclic class of translocator protein (TSPO) ligands first described by Okubo et al. was synthesised and evaluated as potential positron emitting tomography (PET) ligands for imaging TPSO in vivo. Fluorine-18 labelling of the molecules was achieved using direct radiolabelling or synthon based labelling approaches. Several of the ligands prepared have promising profiles as potential TSPO PET imaging ligands.
CiteXplore: 23489633
DOI: 10.1016/j.bmcl.2013.02.057
Patent ID: ┄