Document Report Card

ID: ALA2375298

Journal: J Nat Prod

Title: Isolation, structure determination, and anti-HIV evaluation of tigliane-type diterpenes and biflavonoid from Stellera chamaejasme.

Authors: Asada Y, Sukemori A, Watanabe T, Malla KJ, Yoshikawa T, Li W, Kuang X, Koike K, Chen CH, Akiyama T, Qian K, Nakagawa-Goto K, Morris-Natschke SL, Lu Y, Lee KH.

Abstract: Five novel tigliane-type diterpenes, stelleracins A-E (3-7), a novel flavanone dimer, chamaeflavone A (8), and six known compounds were isolated from the roots of Stellera chamaejasme. Their structures were elucidated by extensive spectroscopic analyses. The isolated compounds were evaluated for anti-HIV activity in MT4 cells. New compounds 3-5 showed potent anti-HIV activity (EC90 0.00056-0.0068 μM) and relatively low or no cytotoxicity (IC50 4.4-17.2 μM). These new compounds represent promising new leads for development into anti-AIDS clinical trial candidates.

CiteXplore: 23611151

DOI: 10.1021/np300815t