Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase.

ID: ALA2375319

Journal: Bioorg Med Chem Lett

Title: Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase.

Authors: Fullam E, Talbot J, Abuhammed A, Westwood I, Davies SG, Russell AJ, Sim E.

Abstract: The synthesis and inhibitory potencies of a novel series of 3,5-diaryl-1H-pyrazoles as specific inhibitors of prokaryotic arylamine N-acetyltransferase enzymes is described. The series is based on hit compound 1 3,5-diaryl-1H-pyrazole identified from a high-throughout screen that has been carried out previously and found to inhibit the growth of Mycobacterium tuberculosis.

CiteXplore: 23518278

DOI: 10.1016/j.bmcl.2013.02.052

Patent ID: ┄