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ID: ALA2380251
Journal: Bioorg Med Chem Lett
Title: Antiproliferative activity of 2,3-disubstituted indoles toward apoptosis-resistant cancers cells.
Authors: Magedov IV, Lefranc F, Frolova LV, Banuls LM, Peretti AS, Rogelj S, Mathieu V, Kiss R, Kornienko A.
Abstract: Many types of cancer, including glioma, melanoma, NSCLC, among others, are resistant to apoptosis induction and poorly responsive to current therapies with propaptotic agents. We describe a series of 2,3-disubstituted indoles, which display cytostatic rather than cytotoxic effects in cancer cells, and serve as a new chemical scaffold to develop anticancer agents capable of combating apoptosis-resistant cancers associated with dismal prognoses.
CiteXplore: 23622980