New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi.

ID: ALA2384990

Journal: ACS Med Chem Lett

Title: New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi.

Authors: Friggeri L, Scipione L, Costi R, Kaiser M, Moraca F, Zamperini C, Botta B, Di Santo R, De Vita D, Brun R, Tortorella S.

Abstract: The antiparasitic activity of azole and new 4-aminopyridine derivatives has been investigated. The imidazoles 1 and 3-5 showed a potent in vitro antichagasic activity with IC50 values in the low nanomolar concentration range. The (S)-1, (S)-3, and (S)-5 enantiomers showed (up to) a thousand-fold higher activity than the reference drug benznidazole and furthermore low cytotoxicity on rat myogenic L6 cells.

CiteXplore: 24900706

DOI: 10.1021/ml400039r

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