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ID: ALA2384997
Journal: Bioorg Med Chem Lett
Title: 2-(1H-Pyrazol-4-yl)acetic acids as CRTh2 antagonists.
Authors: Andrés M, Bravo M, Buil MA, Calbet M, Castro J, Domènech T, Eichhorn P, Ferrer M, Gómez E, Lehner MD, Moreno I, Roberts RS, Sevilla S.
Abstract: High throughput screening identified the pyrazole-4-acetic acid substructure as CRTh2 receptor antagonists. Optimisation of the compounds uncovered a tight SAR but also identified some low nanomolar inhibitors.
CiteXplore: 23601708