Document Report Card

Basic Information

ID: ALA2396596

Journal: Bioorg Med Chem Lett

Title: Anthraquinone derivatives from Rumex plants and endophytic Aspergillus fumigatus and their effects on diabetic nephropathy.

Authors: Yang Y, Yan YM, Wei W, Luo J, Zhang LS, Zhou XJ, Wang PC, Yang YX, Cheng YX.

Abstract: Two new oxanthrone C-glycosides, patientosides A (14) and B (15), together with three known ones (11-13), were isolated from Rumex patientia. Their structures were identified on the basis of spectroscopic methods. The absolute configuration for 14 and 15 were deduced by analysis of their CD spectra and comparison with those of known similar compounds. Compounds 11-15, and 14 known anthraquinones (1-4, 6-10, 16-20) previously isolated from Rumex nepalensis, Rumex hastatus, and endophytic Aspergillus fumigatus, respectively, as well as a commercially available compound rhein (5) were evaluated for their inhibitory effects on IL-6 and extracellular matrix production in mesangial cells.

CiteXplore: 23683594

DOI: 10.1016/j.bmcl.2013.04.059