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ID: ALA2401643
Journal: Bioorg Med Chem Lett
Title: The discovery of potent selective NPY Y(2) antagonists.
Authors: Chai W, Wong VD, Nepomuceno D, Bonaventure P, Lovenberg TW, Carruthers NI.
Abstract: A series of small molecules with a piperidinyl core were synthesized and tested for binding affinity (IC50) at human Neuropeptide Y Y2 receptor. Various amide related analogs (ureas, reversed amides, and sulfonamides) were evaluated. Several potent and selective NPY Y2 antagonists were identified.
CiteXplore: 23756063