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ID: ALA2401705
Journal: Bioorg Med Chem Lett
Title: Discovery of triazines as potent, selective and orally active PDE4 inhibitors.
Authors: Gewald R, Grunwald C, Egerland U.
Abstract: Expanding on HTS hit 4 afforded a series of [1,3,5]triazine derivatives as novel PDE4 inhibitors. The SAR development and optimization process with the emphasis on ligand efficiency and physicochemical properties led to the discovery of compound 44 as a potent, selective and orally active PDE4 inhibitor.
CiteXplore: 23806553