Document Report Card

ID: ALA2417480

Journal: J Nat Prod

Title: Bioactive polyprenylated acylphloroglucinol derivatives from Hypericum cohaerens.

Authors: Liu X, Yang XW, Chen CQ, Wu CY, Zhang JJ, Ma JZ, Wang H, Yang LX, Xu G.

Abstract: Nine new polyprenylated acylphloroglucinol derivatives, hypercohins B-J (1-9), and nine known analogues were isolated from the aerial parts of Hypericum cohaerens. The structures of 1-9 were elucidated based on spectroscopic analysis, and the absolute configuration of 1 was confirmed by X-ray crystallographic analysis. The inhibitory activities of these isolates on acetylcholinesterase and five human tumor cell lines were tested, and hypercohins B-D (1-3) exhibited moderate inhibitory activity (IC₅₀ 5.8-17.9 μM) against the tested tumor cell lines.

CiteXplore: 23957453

DOI: 10.1021/np400287r