Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines.
Basic Information
ID: ALA2424632
Journal: Eur J Med Chem
Title: Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines.
Authors: Imramovský A, Jorda R, Pauk K, Rezníčková E, Dušek J, Hanusek J, Kryštof V.
Abstract: Variously substituted 2-hydroxy-N-(arylalkyl)benzamides were prepared and screened for antiproliferative and cytotoxic activity in cancer cell lines in vitro. Five compounds, out of 33 showed single-digit micromolar IC50 values against several human cancer cell lines. One of the most potent compounds N-((R)-1-(4-chlorophenylcarbamoyl)-2-phenylethyl)-5-chloro-2-hydroxybenzamide (6k) reduced proliferation and induced apoptosis in the melanoma cell line G361 in a dose-dependent manner, as shown by decrease in 5-bromo-2'-deoxyuridine incorporation and increase in several apoptotic markers, including subdiploid population increase, activation of caspases and site-specific poly-(ADP-ribose)polymerase (PARP) cleavage.
CiteXplore: 23981532
DOI: 10.1016/j.ejmech.2013.08.009
Patent ID: ┄