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ID: ALA2429801
Journal: Bioorg Med Chem Lett
Title: 3-Ylidenephthalides as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators.
Authors: Ortar G, Schiano Moriello A, Morera E, Nalli M, Di Marzo V, De Petrocellis L.
Abstract: Following the recent identification of the naturally occurring 3-ylidene-4,5-dihydrophthalide ligustilide and its oxidation product dehydroligustilide as novel TRPA1 modulators, a series of seventeen 3-ylidenephthalides was synthesized and tested on TRPA1 and TRPM8 channels. Most of these compounds acted as strong modulators of the two channel types with EC50 and/or IC50 values distinctly lower than those of the reference compounds.
CiteXplore: 23993334