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ID: ALA2434955
Journal: Bioorg Med Chem Lett
Title: Potent inhibition of norovirus by dipeptidyl α-hydroxyphosphonate transition state mimics.
Authors: Mandadapu SR, Gunnam MR, Galasiti Kankanamalage AC, Uy RA, Alliston KR, Lushington GH, Kim Y, Chang KO, Groutas WC.
Abstract: The design, synthesis, and evaluation of a series of dipeptidyl α-hydroxyphosphonates is reported. The synthesized compounds displayed high anti-norovirus activity in a cell-based replicon system, as well as high enzyme selectivity.
CiteXplore: 24054123