Antimalarial activity of compounds comprising a primary benzene sulfonamide fragment.
Basic Information
ID: ALA2440073
Journal: Bioorg Med Chem Lett
Title: Antimalarial activity of compounds comprising a primary benzene sulfonamide fragment.
Authors: Andrews KT, Fisher GM, Sumanadasa SD, Skinner-Adams T, Moeker J, Lopez M, Poulsen SA.
Abstract: Despite the urgent need for effective antimalarial drugs with novel modes of action no new chemical class of antimalarial drug has been approved for use since 1996. To address this, we have used a rational approach to investigate compounds comprising the primary benzene sulfonamide fragment as a potential new antimalarial chemotype. We report the in vitro activity against Plasmodium falciparum drug sensitive (3D7) and resistant (Dd2) parasites for a panel of fourteen primary benzene sulfonamide compounds. Our findings provide a platform to support the further evaluation of primary benzene sulfonamides as a new antimalarial chemotype, including the identification of the target of these compounds in the parasite.
CiteXplore: 24084158
DOI: 10.1016/j.bmcl.2013.09.015
Patent ID: ┄