Discovery of bis-aromatic ring neonicotinoid analogues fixed as cis-configuration: Synthesis, insecticidal activities, and molecular docking studies.
Basic Information
ID: ALA3045685
Journal: Bioorg Med Chem Lett
Title: Discovery of bis-aromatic ring neonicotinoid analogues fixed as cis-configuration: Synthesis, insecticidal activities, and molecular docking studies.
Authors: Sun C, Jin J, Zhu J, Wang H, Yang D, Xing J.
Abstract: A novel series of bis-aromatic ring neonicotinoid analogues (1a-1l, 2a-2c), were designed and prepared by introducing a new substituted aromatic ring into nitenpyram and forming a tetrahydropyrimidine ring, with the cis-configuration confirmed by X-ray diffraction. Preliminary bioassays showed most analogues exhibited good insecticidal activities at 100mg/L, and compound 1d and 2a were highly potent even at 10mg/L. Modeling the ligand-receptor complexes by molecular docking study explained the structure-activity relationships observed in vitro, which may provide some useful information for future design of new insecticides.
CiteXplore: 20452211
DOI: 10.1016/j.bmcl.2010.04.050
Patent ID: ┄