Document Report Card

ID: ALA3045837

Journal: J Agric Food Chem

Title: Tobacco mosaic virus (TMV) inhibitors from Picrasma quassioides Benn.

Authors: Chen J, Yan XH, Dong JH, Sang P, Fang X, Di YT, Zhang ZK, Hao XJ.

Abstract: To investigate natural inhibitors against tobacco mosaic virus (TMV) from plants, 10 known beta-carboline alkaloids and one quassinoid have been isolated from MeOH extract of the wood of Picrasma quassioides Benn. These compounds were screened for their inhibitory activities against tobacco mosaic virus (TMV). The activity of each compound against TMV infection and replication was tested using a half-leaf assay method, a leaf-disk method, and Western blotting analyses. All of the beta-carboline alkaloids showed moderate anti-TMV activities and exhibited synergistic effects when combined with the quassinoid nigakilactone B (11). To our knowledge, this is the first report on anti-TMV activity of beta-carbolines and their synergistic effects against TMV when combined with a quassinoid.

CiteXplore: 19586051

DOI: 10.1021/jf901632j