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ID: ALA3045958
Journal: Bioorg Med Chem Lett
Title: The design and synthesis of inhibitors of adenosine 5'-monophosphate deaminase.
Authors: Lindell SD, Moloney BA, Hewitt BD, Earnshaw CG, Dudfield PJ, Dancer JE.
Abstract: Carbocylic coformycin (4) is a potent herbicide whose primary mode of action involves inhibition of adenosine 5'-monophosphate deaminase (AMPDA) following phosphorylation of the 5'-hydroxyl group in vivo. The search for more stable and accessible structures led to the synthesis of carbocyclic nebularine (8) and deaminoformycin (10). The latter compound is a good herbicide and its corresponding 5'-monophosphate 14 is a strong inhibitor of plant AMPDA (IC50 100 nM).
CiteXplore: 10450967