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ID: ALA3046420
Journal: Bioorg Med Chem Lett
Title: A new antifungal and cytotoxic C-methylated flavone glycoside from Picea neoveitchii.
Authors: Chen WQ, Song ZJ, Xu HH.
Abstract: A new C-methylated flavone glycoside, 5,7-dihydroxy-3-methoxy-6-C-methylflavone 8,4'-di-O-β-D-glucopyranoside (1), was isolated from the twigs and leaves of Picea neoveitchii Mast, together with eight known compounds, 5,7,8,4'-tetrahydroxy-3-methoxy-6-methylflavone 8-O-β-D-glucopyranoside (2) kaempferol 3,4'-di-O-β-D-glucopyranoside (3), apigenin 7-O-β-D-glucopyranoside (4), tiliroside (5), massonianoside B (6), umbeliferone 7-O-β-D-glucopyranoside (7), dihydroconiferin (8) and gleditschiaside A (9). Their structures were elucidated on the basis of analyses of spectroscopic data. Compound 1 showed moderate antifungal activity against tested plant pathogens (Pyricularia grisea (Cooke) Sacc., Sclerotium rocfsii Sacc. and Alternaria mali Roberts), however, compounds 2 and 5 had obvious inhibitory effect against S. rocfsii and A. mali, respectively. Compounds 1, 2, 3 and 9 also exhibited potent cytotoxicity against Spodoptera litura Fabricius cells.
CiteXplore: 22901896