Document Report Card

ID: ALA3046491

Journal: J Agric Food Chem

Title: cis-Configuration: a new tactic/rationale for neonicotinoid molecular design.

Authors: Shao X, Lee PW, Liu Z, Xu X, Li Z, Qian X.

Abstract: Resistance development and limited lepidopteran activities call for the discovery of "super-neonicotinoids" solving these problems. Compounds with the cis-configuration offer an opportunity for further optimization. Fixing the nitro group in the cis-configuration provided a new approach for neonicotinoid molecular design. Introductions of the heterocycle or a bulky group are two synthesis concepts to fix the cis-configuration of the nitro group. The design, synthesis, bioactivity, and preliminary modes of action of five types of cis-neonicotinoids are reviewed. cis- and trans-neonicotinoids have some differences in bioactivities and modes of action. This study focused, especially, on the reaction diversities of nitromethylene analogues of imidacloprid with various aldehydes.

CiteXplore: 21043520

DOI: 10.1021/jf103499x