Fungicidal sesquiterpene dialdehyde cinnamates from Pseudowintera axillaris.
Basic Information
ID: ALA3046621
Journal: J Agric Food Chem
Title: Fungicidal sesquiterpene dialdehyde cinnamates from Pseudowintera axillaris.
Authors: Brennan NJ, Larsen L, Lorimer SD, Perry NB, Chapin EL, Werk TL, Henry MJ, Hahn DR.
Abstract: Bioactivity-directed separation of a foliage extract from the New Zealand shrub Pseudowintera axillaris led to a compound with fungicidal activity against the plant pathogen Phytophthora infestans. This was identified as a new sesquiterpene dialdehyde cinnamate named paxidal. Two 6-hydroxy derivatives were present at lower levels in the extract. A further nine derivatives were synthesized from these natural products for a structure-activity study against a range of important food crop pathogens. The cinnamate group was important for fungicidal effects, and protection of the dialdehyde as a dimethyl acetal gave more potent, broader spectrum activity.
CiteXplore: 16417306
DOI: 10.1021/jf052585s
Patent ID: ┄