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ID: ALA3085697
Journal: Bioorg Med Chem Lett
Title: Design and synthesis of aryl sulfonamide-based nonsteroidal mineralocorticoid receptor antagonists.
Authors: Futatsugi K, Piotrowski DW, Casimiro-Garcia A, Robinson S, Sammons M, Loria PM, Banker ME, Petersen DN, Schmidt NJ.
Abstract: Hit-to-lead medicinal chemistry efforts are described starting from a screening hit 1, leading to a new class of aryl sulfonamide-based MR antagonist, exemplified by 17, that possesses favourable MR binding affinity, selectivity profile against closely related NHRs, physicochemical properties and metabolic stability.
CiteXplore: 24157365