Basic Information
ID: ALA3102713
Journal: Bioorg Med Chem
Title: The cytotoxic effect of 2-acylated-1,4-naphthohydroquinones on leukemia/lymphoma cells.
Authors: Pedroza DA, De Leon F, Varela-Ramirez A, Lema C, Aguilera RJ, Mito S.
Abstract: Here, we tested seven 2-acylated-1,4-hydronaphthoquinones for their cytotoxic effects on a panel of cancer lymphoma/leukemia cells and compared to a non-cancer origin cell line. Several naphthohydroquinones exhibited selective cytotoxic effects on lymphoma/leukemia cells with lowest activity on non-cancer cells. The mode of cell death induced by an acylated naphthohydroquinone, which has a long alkyl chain, was found to be via apoptosis. Furthermore, the naphthohydroquinone provoked mitochondria depolarization and activation of its downstream effector, caspase-3, thus implicating the intrinsic apoptotic pathway as its mechanism to exert cell death.
CiteXplore: 24368029
DOI: 10.1016/j.bmc.2013.12.007
Patent ID: ┄
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