Anticomplement monoterpenoid glucosides from the root bark of Paeonia suffruticosa.

ID: ALA3102746

Journal: J Nat Prod

Title: Anticomplement monoterpenoid glucosides from the root bark of Paeonia suffruticosa.

Authors: Song WH, Cheng ZH, Chen DF.

Abstract: Six new (1-6) and 19 known monoterpenoid glucosides were isolated from the root bark of Paeonia suffruticosa. The monoterpenoid glucosides 1, 2, 7, 10-19, and 22 exhibited anticomplement effects with CH50 and AP50 values ranging from 0.14 to 2.67 mM and 0.25 to 3.67 mM, respectively. In a mechanistic study, suffrupaeoniflorin A (1) interacted with C1q, C3, C5, and C9, while galloylpaeoniflorin (12) and galloyloxypaeoniflorin (19) acted on C1q, C3, and C5 components in the complement activation cascade.

CiteXplore: 24377852

DOI: 10.1021/np400571x

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