Mycoleptones A-C and polyketides from the endophyte Mycoleptodiscus indicus.
Basic Information
ID: ALA3102817
Journal: J Nat Prod
Title: Mycoleptones A-C and polyketides from the endophyte Mycoleptodiscus indicus.
Authors: Andrioli WJ, Conti R, Araújo MJ, Zanasi R, Cavalcanti BC, Manfrim V, Toledo JS, Tedesco D, de Moraes MO, Pessoa C, Cruz AK, Bertucci C, Sabino J, Nanayakkara DN, Pupo MT, Bastos JK.
Abstract: Three new azaphilones with an unusual methylene bridge, named mycoleptones A, B, and C (2, 4, and 5), were isolated from cultures of Mycoleptodiscus indicus, a fungus associated with the South American medicinal plant Borreria verticillata. Additionally, four known polyketides, austdiol (1), eugenitin (3), 6-methoxyeugenin (6), and 9-hydroxyeugenin (7), were also isolated. The structural characterization of compounds was carried out by nuclear magnetic resonance spectroscopy, high-resolution mass spectrometry, electronic circular dichroism spectroscopy, time-dependent density functional theory calculations, and X-ray crystallography. Compounds 1-9 were weakly active when tested in antileishmanial and cytotoxicity assays.
CiteXplore: 24387625
DOI: 10.1021/np4006822
Patent ID: ┄