Document Report Card

ID: ALA3108662

Journal: J Med Chem

Title: Controlled oxygen release from pyridone endoperoxides promotes cell survival under anoxic conditions.

Authors: Benz S, Nötzli S, Siegel JS, Eberli D, Jessen HJ.

Abstract: In tissue engineering, survival of larger constructs remains challenging due to limited supply of oxygen caused by a lack of early vascularization. Controlled release of oxygen from small organic molecules represents a possible strategy to prevent cell death under anoxic conditions. A comprehensive study of methylated pyridone-derived endoperoxides has led to the development of water-soluble molecules that undergo retro-Diels-Alder reactions in aqueous environment releasing oxygen in high yield and with half-lives of up to 13 h. These molecules in combination with vitamin C as singlet oxygen quencher significantly improved survival of 3T3 fibroblasts and rat smooth muscle cells challenged with oxygen-depleted conditions.

CiteXplore: 24299550

DOI: 10.1021/jm4016137