Document Report Card

ID: ALA3108777

Journal: J Nat Prod

Title: Isochromans and α-pyrones from Penicillium corylophilum.

Authors: McMullin DR, Nsiama TK, Miller JD.

Abstract: Seven new secondary metabolites, four isochromans (1-4) and three α-pyrones (5-7), were isolated from Penicillium corylophilum DAOM 242293 collected from a damp building in Halifax, Canada. Their structures were elucidated by HRESIMS, 1D and 2D NMR, chemical derivatization, ORD, UV, and comparison to the literature. Related isochromans have previously been reported from other Penicillium species; however, to our knowledge this is the first report of α-pyrones from P. corylophilum. Compounds 1-4 demonstrated antifungal activity against Saccharomyces cerevisiae at 100 μg mL(-1).

CiteXplore: 24456578

DOI: 10.1021/np4005486