Chemical constituents of Plectranthus amboinicus and the synthetic analogs possessing anti-inflammatory activity.
Basic Information
ID: ALA3112402
Journal: Bioorg Med Chem
Title: Chemical constituents of Plectranthus amboinicus and the synthetic analogs possessing anti-inflammatory activity.
Authors: Chen YS, Yu HM, Shie JJ, Cheng TJ, Wu CY, Fang JM, Wong CH.
Abstract: This study demonstrates that compounds 1-4 from an extract of Plectranthus amboinicus inhibit the binding of AP-1 to its consensus DNA sequence. Thymoquinone (5) was further identified as a nonpolar ingredient from the hexane extract of P. amboinicus to suppress the expression of lipopolysaccharide-induced tumor necrosis factor-alpha (TNF-α). We then synthesized 2-alkylidenyl-4-cyclopentene-1,3-diones as the designed biomimetics of thymoquinone, and found that compounds 8a, 8b and 8d were more potent TNF-α inhibitors.
CiteXplore: 24491635
DOI: 10.1016/j.bmc.2014.01.009
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