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ID: ALA3112458

Journal: Bioorg Med Chem Lett

Title: A biochemical screen for GroEL/GroES inhibitors.

Authors: Johnson SM, Sharif O, Mak PA, Wang HT, Engels IH, Brinker A, Schultz PG, Horwich AL, Chapman E.

Abstract: High-throughput screening of 700,000 small molecules has identified 235 inhibitors of the GroEL/GroES-mediated refolding cycle. Dose-response analysis of a subset of these hits revealed that 21 compounds are potent inhibitors of GroEL/GroES-mediated refolding (IC50 <10 μM). The screening results presented herein represent the first steps in a broader aim of developing molecular probes to study chaperonin biochemistry and physiology.

CiteXplore: 24418775

DOI: 10.1016/j.bmcl.2013.12.100