Design, synthesis and biological evaluation of novel peptide MC62 analogues as potential antihyperglycemic agents.
Basic Information
ID: ALA3112516
Journal: Eur J Med Chem
Title: Design, synthesis and biological evaluation of novel peptide MC62 analogues as potential antihyperglycemic agents.
Authors: Yang B, Mei Y, Wang X, Deng X, Qian H, Huang W.
Abstract: Two series of peptide MC62 analogues were synthesized, characterized and evaluated for their antihyperglycemic effects. Structure-activity relationship studies of the first series indicated that antihyperglycemic effects were correlated to residues 4, 5, 7 and 8. Peptide I-6 exhibited higher antihyperglycemic activity than the MC62 parent peptide, and was chosen for further modification. Incorporation of Met at position 3 increased potency further and generated II-3, which was screened in vivo and in vitro using exenatide (Ex-4) and GLP-1 as positive controls. The results showed that the antihyperglycemic and antioxidative activities of II-3 were comparable to the positive controls, suggesting II-3 could be a candidate for use as a future diabetic treatment.
CiteXplore: 24384551
DOI: 10.1016/j.ejmech.2013.11.043
Patent ID: ┄