Bioactive limonoids from the leaves of Azaridachta indica (Neem).

ID: ALA3120057

Journal: J Nat Prod

Title: Bioactive limonoids from the leaves of Azaridachta indica (Neem).

Authors: Gualtieri MJ, Malafronte N, Vassallo A, Braca A, Cotugno R, Vasaturo M, De Tommasi N, Dal Piaz F.

Abstract: Eight new limonoids (1-8) and one new phenol glycoside (9), along with six known compounds, were isolated from the leaves of Azaridachta indica. The structures of 1-9 were elucidated on the basis of spectroscopic data analysis. Compounds isolated were assayed for their cytotoxicity against different cancer cell lines. Moreover, their ability to interact with the molecular chaperone Hsp90, affecting its biological activity, was tested.

CiteXplore: 24499352

DOI: 10.1021/np400863d

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