Design of symmetrical and nonsymmetrical N,N-dimethylaminopyridine derivatives as highly potent choline kinase alpha inhibitors.

ID: ALA3217582

Journal: Medchemcomm

Title: Design of symmetrical and nonsymmetrical N,N-dimethylaminopyridine derivatives as highly potent choline kinase alpha inhibitors.

Authors: Trousil S, Carroll L, Kalusa A, Aberg O, Kaliszczak M, Aboagye EO.

Abstract: Choline kinase alpha is hyperactivated in many solid tumours and regulates malignant progression, making it a promising cancer drug target. The successful design and synthesis of novel inhibitors with high cellular activity are described.

CiteXplore: 24976941

DOI: 10.1039/c3md00068k

Patent ID: ┄