Document Report Card

ID: ALA3217705

Journal: Medchemcomm

Title: Synthesis and evaluation of stable substrate analogs as potential modulators of cyclodiphosphate synthase IspF.

Authors: Bitok JK, Meyers CF.

Abstract: Stable IspF substrate analogs were synthesized. In the presence of substrate analogs, the E. coli IspF-MEP complex shows activities distinct from IspF, and bisphosphonates (BP) behave differently than their diphosphate (DP) counterparts. Bisphosphonate analogs activate and/or stabilize IspF, and only the closest structural substrate analog weakly inhibits the IspF-MEP complex.

CiteXplore: 23509611

DOI: 10.1039/c2md20175e