Phosphonate analogue of 2'-deoxy-5-fluorouridylic acid.

Basic Information

ID: ALA3227928

Journal: J Med Chem

Title: Phosphonate analogue of 2'-deoxy-5-fluorouridylic acid.

Authors: Montgomery JA, Thomas HJ, Kisliuk RL, Gaumont Y.

Abstract: The phosphonate analogue (6) of 2'-deoxy-5-fluorouridylic acid has been prepared via a Pfitzner--Moffatt oxidation and Witting reaction. This compound was found to inhibit thymidylate synthetase from three sources and to be cytotoxic to H.Ep.-2 cells in culture.

CiteXplore: 423172

DOI: 10.1021/jm00187a024

Patent ID: