Document Report Card
Basic Information
ID: ALA3227941
Journal: J Med Chem
Title: 3-Substituted adenines. In vitro enzyme inhibition and antiviral activity.
Authors: Fujii T, Walker GC, Leonard NJ.
Abstract: The direct alkylation of adenine at the 3 position has been extended to produce series of 3-alkyl-, 3-allyl-, and 3-(substituted benzyl)adenines. When these compounds were tested for enzyme inhibition and antiviral activity in vitro, 3-n-pentyladenine was found to be the most active compound in inhibiting the enzyme dopamine-beta-hydroxylase, and 3-(2-bromobenzyl)adenine showed the most striking inhibition of multiplication of Vaccinia virus and of Herpes simplex virus in tissue culture.
CiteXplore: 218008
DOI: 10.1021/jm00188a003