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ID: ALA3227941

Journal: J Med Chem

Title: 3-Substituted adenines. In vitro enzyme inhibition and antiviral activity.

Authors: Fujii T, Walker GC, Leonard NJ.

Abstract: The direct alkylation of adenine at the 3 position has been extended to produce series of 3-alkyl-, 3-allyl-, and 3-(substituted benzyl)adenines. When these compounds were tested for enzyme inhibition and antiviral activity in vitro, 3-n-pentyladenine was found to be the most active compound in inhibiting the enzyme dopamine-beta-hydroxylase, and 3-(2-bromobenzyl)adenine showed the most striking inhibition of multiplication of Vaccinia virus and of Herpes simplex virus in tissue culture.

CiteXplore: 218008

DOI: 10.1021/jm00188a003