Document Report Card

ID: ALA3228039

Journal: J Med Chem

Title: Synthesis and evaluation of the antiovulatory activity of a variety of melatonin analogues.

Authors: Flaugh ME, Crowell TA, Clemens JA, Sawyer BD.

Abstract: A series of melatonin analogues was synthesized and examined for ovulation-blocking activity. Deviation from the 5-methoxy group or substitution of the 1 position prevented activity. Activity was not particularly sensitive to minor variations in the N-acyl group nor was it significantly altered by methylation of position 2 or the alpha-methylene; however, a pronounced enhancement resulted from halogenation of the 6 position.

CiteXplore: 423184

DOI: 10.1021/jm00187a015