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ID: ALA3232758
Journal: Bioorg Med Chem Lett
Title: Synthesis and evaluation of carbon-linked analogs of dual orexin receptor antagonist filorexant.
Authors: Kuduk SD, Skudlarek JW, Di Marco CN, Bruno JG, Pausch MA, O'Brien JA, Cabalu TD, Stevens J, Brunner J, Tannenbaum PL, Gotter AL, Winrow CJ, Renger JJ, Coleman PJ.
Abstract: Analogs of the dual orexin receptor antagonist filorexant were prepared. Replacement of the ether linkage proved highly sensitive toward modification with an acetylene linkage providing compounds with the best in vitro and in vivo potency profiles.
CiteXplore: 24630562